Non-Secretory Plasma Cell Leukemia

Non-secretory multiple myeloma presenting as primary plasma cell leukaemia.

A case of non-secretory multiple myeloma presenting as primary plasma cell leukaemia in a 65 year old woman is presented. Bone pain was the initial clinical manifestation. Laboratory analysis showed 20% of circulating immature plasma cells. Despite the presence of osteolytic lesions, no M-component could be demonstrated in serum protein electrophoresis, and serum and urine immunoelectrophoresis...

A Rare Case of Non Secretory Plasma Cell Leukemia with Unusual Morphology and Aberrant Expression of CD23 and CD56

Primary non-secretory Plasma cell leukemiaisa rare diagnosis with only few cases reported so far. Here we report a case of a non secretory Plasma cell leukemia diagnosed on flow cytometry, as atypical morphology and negative serum and urine protein electrophoresis made it difficult to come to a conclusive diagnosis based on morphology.

Plasma cell leukemia

Paciente do gênero feminino, 74 anos, procurou o hospital com quadro de insuficiência renal e lesões líticas em coluna vertebral, sendo feito diagnóstico de mieloma múltiplo IgG kappa. Na ocasião, observaram-se monossomia do cromossomo 13 e rearranjo do IgH no FISH. A paciente foi submetida a cinco ciclos de VMP (bortezomibe, melfalan e prednisona) com resposta com pleta; foi iniciada a manuten...

Plasma cell leukemia.

Secondary plasma cell leukemia.

Plasma cell leukemia (PCL) is a rare disease and is the least common variant of multiple myeloma accounting for 2-3% of all plasma cell dyscrasias. We report a patient who was diagnosed with multiple myeloma, 12 months earlier; he was treated with VBCMP, VCMP regime, and after 12 months he presented of high grade fever, weakness, palpitations, loss of appetite, bone pains, dyspnea. Initial eval...